The invention relates to a method which is capable of detecting dissolution rates of three components including amlodipine, valsartan and a hydrochlorothiazide compound preparation at the same time. According to the method, phosphate buffer with a PH value of 6.8 is used as a dissolution medium, and content of the three components in the dissolution medium is detected with a method of high performance liquid chromatography (HPLC). The chromatographic condition is that the C18 chromatographic column and phosphate aqueous solution - acetonitrile mixed solution are mobile phases, wherein the PH value of the phosphate aqueous solution is 3.0 - 5.0, a volume ratio of the phosphate aqueous solution to acetonitrile is 50:50 - 60:40, and the detection wavelength is 220-240 nm. The method is capable of achieving effective separation of the three components, detecting the content of the three components in the dissolution medium fast and accurately and further calculating the dissolution rate.