Methods and apparatus to protect segments of memory are disclosed herein. An example method includes intercepting an interrupt request indicating an error; determining whether a first segment of memory is corrupt, the first segment of memory being designated as a protected region of memory; when the protected region of memory is corrupt, repairing the corrupted region of memory using a parity block of code; and in response to validating the protected region of memory, generating an interrupt enabling a utilization of code stored in the protected region of memory to handle the error associated with the interrupt request.