The invention relates to a tobacco culturing method applying large holes for concentrated fertilization. The method is applicable to plain areas of Henan province, and mainly comprises the steps that a base fertilizer is not applied in a culturing process; according to the planting density (16500-18000 plants/hm<2>), the large holes are dug at central positions of tobacco plants planted on a tobacco ridge in a tobacco seedling transplanting process; and various fertilizers are mixed uniformly, applied in the holes according to the calculated fertilization amount of each plant, and sealed after being mixed with soil in the holes sufficiently and uniformly. According to the method, soil water and fertilizer nutrition absorption of the tobacco plants and coordination of water, the fertilizers, air and heat are facilitated; a supply of mineral elements such as N, P,K and Cl is optimized; root development and thickening of the tobacco plants can be facilitated; the disease-resistant ability of tobaccos is improved; the growth advantage of a whole growth period is obvious; resource waste and environmental pollution due to blind fertilization are avoided; the production cost is lowered; effects of oil increasing, aroma enhancing, potassium increasing, alkali reducing, chlorine reducing and starch reducing are exerted in an aspect of improving the quality of tobacco leaves; the internal quality of the tobacco leaves is improved; and economic indicators of the tobacco leaves are increased remarkably.