The present invention relates to a micro-fluidic device comprising a process channel having a top wall, a bottom wall and side walls, the process channel having a height between 0.2 mm and 3 mm, a width between 1.0 and 50 mm and support means within said process channel. The support means extends between the bottom wall and the top wall of the process channel in a direction substantially perpendicularly to the top wall. The micro-fluidic device comprises at least one heat exchange means parallel to the process channel and optionally comprises a static mixing element. The present invention further relates to a kit of parts and a micro-fluidic system comprising such micro-fluidic devices.