Provided is an invoice generation control method and device based on relational operation. The invoice generation control method comprises the steps of analyzing an interface control template protocol to generate a user interface; inputting data information of an invoice in different types through the user interface, conducting the relational operation on input data in the different types according to an analyzed user-defined relation protocol, and obtaining needed printing data; and obtaining form information of the printing data of the invoice by analyzing and printing the control template protocol, printing the invoice according to the obtained form information, and completing control for generating the invoice. The invoice generation control method and device solves the problems that a current network invoice system is poor in generality and not strong in product compatibility, cannot conduct unified management on templates through the website, and does not support the relational operation between billing items of the invoice and the like.