The invention discloses a double-boosting high-voltage pulse power supply. The double-boosting high-voltage pulse power supply comprises a main circuit and a control circuit. In the main circuit, a 220V alternate current power source is sequentially connected with a rectifier circuit, a filter circuit, a Boost circuit, an inverter circuit, a pulse transformer, and a pulse rectifier circuit; and the pulse rectifier circuit outputs a high-voltage pulse finally. In the control circuit, a DSP (digital signal processor) system generates three paths of PWM (pulse width modulation) signals which are connected with three drive circuits through respective PWM amplification circuits; one path PWM signals is used for controlling an IGBT (insulated gate bipolar transistor) in the Boost circuit; and the other two paths of PWM signals are used for controlling an IGBT in the inverter circuit. Both the Boost circuit and the inverter circuit are provided with an IGBT protection circuit; the IGBT protection circuits can input fault signals to a DSP when the IGBTs have a fault; and the DSP can interrupt transmission of the PWM signals immediately, so that the IGBTs are kept in an off state, thereby protecting the overall system.