The invention provides a self-adaption binding method and a device of a printing machine. The method provided by the invention comprises the following steps of: selecting a paper type so as to determine a first binding position according to a binding manner and a printing process set by users, correspondingly adjusting the first binding position according to a revolving angle and direction of a dot matrix content in the printing process, and binding according to the first binding position after adjusting. The invention provides the self-adaption binding device of the printing machine. According to the self-adaption binding method of the printing machine and the device provided by the invention, when the printing dot matrix content is subjected to self-adaption matching in a rotating manner, the binding position is adjusted according to the revolving angle and direction, an inaccurate binding phenomenon is avoided, and the binding efficiency is improved.