The present invention provides a method for preparing flexible highly oriented graphite heat conduction material, comprising the following steps: firstly, purifying expandable graphite; secondly, adding a graphene solution; and thirdly, puffing. According to the present invention, graphene is added to natural graphite calender process, the operation is simple, and implementation is easy. The flexible highly oriented graphite heat conduction material can be compounded with metal, plastic, adhesive sticker, aluminum foil, PET and other materials, and cut in accordance with the requirements of different sizes to meet all the necessary heat management design requirements, and is high in adaptability, and good in using effect. Heat conductivity is substantial increased, while the cost is saved with respect to highly oriented graphite and highly crystallized graphite.