The invention discloses a method and device for maintaining multi-point coordination of user equipment. According to one embodiment of the invention, the method comprises the following steps that a base station receives a receiving timing difference measurement report related to a plurality of cells or a receiving timing different measurement report related to a plurality of transmission points in the same cell, which is provided by the user equipment; and on the basis of the received receiving timing different measurement report, the base station executes operation of maintaining a cooperation set. The method and device can timely and effectively maintain multi-point coordination and improve the system throughput.