The invention provides a control method and device for hot-forming plasticity distribution of high-strength steel. The control method comprises the following steps of: step one, heating a heating region of a mold to an appointed temperature; step two, placing and heating a blank in a heating furnace, so that the blank is austenized; step three, taking out the blank from the heating furnace, placing a part of blank in the heating region of the mold according to actual requirements, and placing the another part of blank in a cooling region of the mold; and step four, moving a press machine downwards so as to drive the mold to be closed, so that the blank in the mold is molded. The control device comprises a low mold seat board, a lower voltage withstanding heat insulation plate, a lower mold heating region insert, a lower mold cooling region insert, an upper mold heating region insert, an upper mold cooling region insert, a heating rod hole, a silicon controlled rectifier, a controller, a thermocouple and a heating rod. The control method and device can ensure that a high-strength steel sheet has different strength and plasticity in different regions.