The invention discloses a method for determining an optimal process parameter combination during manufacturing of a plasma display panel. The method comprises the steps of Step 1, conducting dualization processing on plasma display panel production process data to produce a data set; Step 2, determining all value state combinations of parameters meeting the minimum support degree; and Step 3, determining correlated parameter value states from value state combinations of parameters of the minimum support degree. The method has the advantages of being capable of digging out optimal parameter combinations during manufacturing of the plasma display panel through an association rule analysis method in data mining, effectively substituting for manual analysis and regulation and filling in gaps in analysis of important process parameter combinations during manufacturing of the plasma display panel.