利索-全球专利检索

  1. Login
  2. Sign Up
Invention Grant
CN103239710B 具有抗肿瘤活性的多肽及其用途 有权 转让

具有抗肿瘤活性的多肽及其用途
Abstract:
本发明涉及一种具有抗肿瘤活性的多肽及其用途。该多肽的氨基酸序列如Ⅰ、Ⅱ、Ⅲ、或Ⅳ所示：Ⅰ：FPGSDRF；Ⅱ：X-FPGSDRF；Ⅲ：FPGSDRF-Z；Ⅳ：X-FPGSDRF-Z；其中，氨基酸S经磷酸化修饰，X、Z分别为氨基酸或氨基酸序列；X选自F、(R)9、(R)9-F、6-氨基己酸、6-氨基己酸-F、6-氨基己酸-(R)9、6-氨基己酸-(R)9-F之一；Z选自A、(G)n-RGD、A-(G)n-RGD之一。该多肽可用于制备抗肿瘤药物。本发明多肽序列较短，易于实现规模化生产；在较低剂量下即显示出显著的抗肿瘤活性，与化学药物联合使用可增强化学药物如三氧化二砷（As2O3，ATO）对肿瘤细胞的毒性。本发明多肽对正常组织细胞无毒性，具有广阔的应用前景。
Abstract(English):

Provided is a polypeptide having anti-tumor activity. The amino acid sequence of the polypeptide is FPGSDRF, X-FPGSDRF, FPGSDRF-Z, or X-FPGSDRF-Z, S being a phosphorylated serine residue, X and Z each being an amino acid residue or an amino acid sequence, X being selected from one of F, (R)9, (R)9-F, 6-aminocaproic acid, 6-aminocaproic acid-F, 6-aminocaproic acid-(R)9, and 6-aminocaproic acid-(R)9-F, and Z being selected from one of A, (G) n-RGD, and A-(G)n-RGD. The polypeptide has no toxicity for normal histocytes. However, when being used with chemicals (such as arsenic trioxide), the polypeptide can increase toxicity for tumor cells. Also provided are uses of the polypeptide for preparing anti-tumor drugs.

Public/Granted literature
Patent Agency Ranking
0/0