The invention discloses a minimum break point set (MBPS) updating method suitable for any topological structure modification. The method comprises the following steps: when a power grid topological structure is modified, acquiring a modified protection set through updating a terminal break point of the MBPS before the power grid topological structure is modified; acquiring a newly increased protection set according to variation characteristics of a simple return circuit, taking the modified protection set as a setting starting point to perform setting calculation, and acquiring the protection set that can not be set; performing union set calculation on the newly increased break point set and the modified protection set to acquire the break point set after the topological structure is modified; selecting nonterminal break point of the modified protection set, taking the set, which is acquired by using the modified protection set to subtract the nonterminal break point, as the setting starting point, performing setting calculation and acquiring the protection set that can not be set; and using the break point set after the topological structure is modified to subtract a redundant break point set so as to acquire the modified MBPS. The method is steady in computational efficiency, does not rely on network structure, and is higher in computation speed.