A screw hole enhanced type large-span glued wooden post and beam connecting structure comprises metal connecting pieces (1). Each metal connecting piece (1) is composed of base boards and an inserting block. One base board is in contact with one face of a glued wooden post (2) and connected with the other base board at the other side of the glued wooden post (2) through bolts, so that each metal connecting piece (1) is fixed on the glued wooden post (2). Each inserting block is inserted in one inserting groove in the end portion of one glued wooden beam (3) and each inserting block is connected with one glued wooden beam (3) through connecting bolts. The screw hole enhanced type large-span glued wooden post and beam connecting structure is characterized in that a GFRP enhanced tube (6) is connected to a through hole in the end portion of each glued wooden beam (3) in a glued mode, wherein the through hole is used for being connected with a connecting bolt in a penetrating mode; each GFRP enhance tube (6) is connected to a bolt hole of a node zone, connected with one glued wooden beam, on one glued wooden post (2) in a glued mode. The screw hole enhanced type large-span glued wooden post and beam connecting structure is capable of improving bearing capacity, reducing concentrated distribution of stress, changing a failure mode of a connected node, facilitating reduction of the size of the connecting structure, and reducing the manufacturing cost of engineering.