The invention discloses an energy-saving domestic architecture with a cast-in-place industrial gypsum bearing wall and a manufacturing method thereof. The method comprises the following steps: pouring industrial gypsum slurry into a wall body template in the field to manufacture the gypsum bearing wall of the domestic architecture; afterwards, performing pouring for gypsum/concrete compound building floor or house cover on the gypsum bearing wall, after the completion of the pouring, erecting a bottom template of the building floor or the house cover in advance; and arranging prefabricated industrial gypsum molded cases onto the bottom template at equal intervals, and performing concrete pouring after bars are arranged among the industrial gypsum molded cases and at the upper parts thereof, so as to manufacture the gypsum/concrete compound building floor or house cover on the gypsum bearing wall body. Due to the adoption of the method, the construction cost is low, no reinforced concrete structure is required for the wall body support, the structure is reliable, the construction is easy, the thermal insulation performance is good and the energy saving effect is obvious. The domestic architecture is particularly suitable for low-storey and small-bay domestic architectures in rural.