The invention discloses a frame number setting apparatus of a machine frame. The frame number setting apparatus comprises a button which is used for setting a frame number of the machine frame, a button operation response unit which is connected with the button and is used for acquiring button operation and converting button operation into frame number information, and a frame number memory unit which is connected with the button operation response unit and is used for receiving and storing the frame number information transmitted by the button operation response unit. The machine frame including the frame number setting apparatus is also disclosed. The frame number setting apparatus of the machine frame sets the frame number by using the button for cooperating with the memory device, is low in device failure rate and high in reliability, reduces occupation of panel space, improves practicality of the panel, and has especially obvious effects on highly integrated equipment. In addition, the frame number can be operated through a local serial port or a remote management interface and can be written directly by software, so that setting methods are diversified.