The invention provides a generalized driving energy analysis method for vibration coupling of a large regional power grid and provincial power grids. The method comprises the following steps: (1), building a static power flow model and a stable calculation model of an interconnected power grid, (2) scanning a small interfering frequency domain characteristic root, and screening a leading electromechanical oscillation mode of the extra-high voltage interconnected power grid and the provincial power grids, (3) determining a call wire between an extra-high voltage communication channel falling point power grid and other provincial power grids, (4) defining generalized driving energy of large-disturbance oscillation of the extra-high voltage power grid and the provincial power grids, (5) determining the relevance of the vibration coupling of the extra-high voltage power grid and the provincial power grids, and (6) analyzing factors which affect the generalized driving energy, and making relevant measures. By means of the method, the vibration coupling characteristics between the extra-high voltage power grid and the provincial power grids are analyzed, on the basis, the measure of reducing the generalized driving energy to relieve the relevant coupling effect is brought forward, and safe and stable operation capacity of the interconnected power grid crossing a large region can be improved.