The invention relates to a highlighted toothpaste composite tube and a manufacturing method of the highlighted toothpaste composite tube. A tube wall of the highlighted toothpaste composite tube comprises a smooth oil layer, a plastic printing layer, a first adhering layer, a vacuum aluminizing polyester layer, a second adhering layer, a blocking layer, a third adhering layer and a plastic heat-sealing layer from outside to inside, wherein the layers are adhered sequentially. The plastic printing layer is a thermoplastic polyethylene film layer. The first adhering layer is a solvent type polyester polyol adhesive layer. Both the second adhering layer and the third adhering layer are ethylene-acrylic copolymer and polyethylene mixing layers. The plastic heat-sealing layer is a thermoplastic polyethylene film layer. The manufacturing method of the highlighted toothpaste composite tube is combined with the advantages of the manufacturing technology of the composite tube and the advantages of the manufacturing technology of an extruding tube, the composite tube is manufactured through the printing process, the dry-type composite process, the extruding composite process, the cutting process, the polishing process, the tube manufacturing process and the like, so that the surface of the manufactured tube is dazzling, bright in color, smooth, flexible and good in barrier performance and rebounding performance. Consumers are easily attracted by the highlighted toothpaste composite tube, the goods shelf effect is good, and the highlighted toothpaste composite tube can be widely used in current toothpaste packing materials.