Embodiments herein relates to a method in a radio base station (12) for handling a timing of uplink transmission from a user equipment (10) to the radio base station (12) in a radio communications network. The user equipment (10) is served in a cell (14) controlled by the radio base station (12), and which radio base station (12) and user equipment (10) are comprised in the radio communications network. The communications in the cell (14) are organized in radio frames comprising subframes. The radio base station (12) receives a first uplink transmission from the user equipment (10) in a subframe related to the radio base station (12). The radio base station then estimates a time parameter value based on a distance between the user equipment (10) and the radio base station (12) when the first uplink transmission is transmitted from the user equipment (10). The radio base station (12) then sets a time value (NTA1) in a message, which time value (NTA1) is to be used to set a timing of a second uplink transmission at the user equipment (10). The time value (NTA1) is based on the estimated time parameter value and a time offset value ([delta]T). The radio base station (12) then transmits the message comprising the time value (NTA1) to the user equipment.