The invention relates to a blood-sugar-lowering medicine composition. The composition is a traditional Chinese medicine composition used for controlling diabetes and related diseases thereof such as complications. The composition is characterized in that the composition is prepared from American ginseng, white mulberry root-bark, mulberry twig, Asiatic pennywort herb, salvia miltiorrhiza, mythic fungus, and tuber fleeceflower root. With the synergetic effect among the components, the components are prepared into oral preparations such as hard capsules, soft capsules, tablets, granules, powders, pills, tea bags, and medicinal wine. The composition can be applied in Chinese patent medicines or health-care foods, and has functions of promoting endogenous insulin secretion, promoting glucose metabolism, controlling weight, lowering blood sugar, lowering blood lipid, lowering blood viscosity, promoting microcirculation, and thus treating diabetes and complications thereof.