The invention discloses a mercury expelling agent. The mercury expelling agent comprises effective components of pearl powder and sea-buckthorn juice, wherein the pearl powder is prepared by physical methods such as ball milling or air jet pulverization, and the mercury expelling agent also comprises pectin, carotene, reduced glutathione and glucan. The mercury expelling agent comprises the following components in percentage by weight: 20%-40% of pearl powder, 1%-5% of sea-buckthorn juice, 2%-7% of milk powder, 1%-2% of pectin, 3%-7% of reduced glutathione, 0.1%-1% of carotene, 0.2%-0.8% of glucan, and the balance of brown sugar. If taken by people getting mercury poisoning, the mercury expelling agent can relieve toxicity of the mercury or even realize detoxification.