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发明公开
CN103405785A GADD45β基因在制备抗膀胱癌药物中的应用 失效 - 权利终止 转让

GADD45β基因在制备抗膀胱癌药物中的应用
摘要：
本发明提供GADD45β基因在制备抗癌药物中的应用，特别是GADD45β基因在制备抗膀胱癌药物中的应用。本发明通过构建GADD45β基因的超表达载体，转染肿瘤细胞，结果表明：转染后的肿瘤细胞中GADD45β基因的mRNA水平显著上调，肿瘤细胞出现变圆，贴壁性变差，细胞活性显著降低85%，最终出现死亡。本发明筛选得到一个高效抑制肿瘤细胞的基因，为新药靶的发现及肿瘤药物设计提供基础数据。
摘要（英）：

The invention provides a use of a gene GADD45 beta in preparation of drugs for treating cancers and especially provides a use of the gene GADD45 beta in preparation of a drug for treating bladder cancer. According to the invention, an over-expression vector of the gene GADD45 beta is constructed and is transferred into tumor cells. A result shows that an mRNA level of the tumor cells with the gene GADD45 beta is improved obviously; roundness of the tumor cells is improved and adherence of the tumor cells is reduced; and tumor cell activity is improved obviously by 85% and tumor cells die finally. The gene GADD45 beta has high tumor cell inhibition activity and provides base data for novel drug target discovery and a tumor-treatment drug design.

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