The invention provides a cement and diatomite stabilized desert sand mixture for constructing a Niger desert highway. For overcoming the deficiencies of the lack of materials which can be used for road building, and high road construction investment in a Niger desert, the mixture comprises desert sand, diatomite and cement, and comprises the components and the contents: 41%-81% of the desert sand, 10%-40% of the diatomite, 7%-12% of water, 2%-7% of the cement, and 0-0.15% of an admixture, wherein all the percentages are the weight percentages. The mixture has the beneficial effects that: the mixture makes full use of the rich desert sand in Niger desert areas and scattered distribution low-grade diatomite resources at local low-lying places, farthest reduces the using amount of clay, gravel, rock, macadam, lime, fly ash, cement, pitch, steel and other commonly used outward transported roadbed and road surface materials, and thereby reducing the cost of projects.