The invention discloses an anti-counterfeiting method of print pictures based on CCD detection and belongs to the field of presswork forgery prevention. The method includes: establishing an anti-counterfeiting information database, embedding anti-counterfeiting information, and detecting the anti-counterfeiting information. Recording in the anti-counterfeiting information database can be established according the need of a unit. The anti-counterfeiting information is embedded by embedding mesh points different in area rate into a half-tone picture, and the mesh points different in area rate are used to express character information. A detection method of the anti-counterfeiting information includes: using CCD equipment to acquire a print picture with embedded anti-counterfeiting information and a print picture with no embedded anti-counterfeiting information, extracting the embedded anti-counterfeiting information by a feature extraction method, determining a printed matter is true if the data matching with that in the database, and determining the printed matter is counterfeited if the data matching with that in the database is not obtained. The method has the advantages that forgery prevention for printed matters such as package and certificates in practical production can be achieved and copying difficulty is increased greatly.