A clamp for a central hole of a sliding fork drilling end surface comprises a base plate; a support, a rotary disc, a left linear guide pair, a right linear guide pair and a power driving mechanism are arranged on the base plate; the rotary disc which is arranged on the base plate is arranged under the support; a positioning V-shaped block with the upward opening is connected to the support detachably; the left linear guide pair and the right linear guide pair are arranged on the left side and right side of the rotary disc; a left sliding block base is connected to the left linear guide pair in a sliding mode; a right sliding block base is connected to the right linear guide pair in a sliding mode; a left clamping V-shaped block is arranged on the right side of the left sliding block base; a right clamping V-shaped block is arranged on the left side of the right sliding block base; openings of the left clamping V-shaped block and the right clamping V-shaped block are oppositely formed; the power driving mechanism is in linkage with the rotary disc, the left sliding block base and the right sliding block base through the transmission mechanism. The clamp for the central hole of the sliding fork drilling end surface has the advantages of improving the product quality and labor intensity of workers, saving machining costs for parts, reducing labor intensity of the workers and reducing machining difficulties of tools.