The invention discloses a method of manufacturing maca kaoliang spirit. The method comprises the following steps that firstly, maca is washed, sun-dried and crushed coarsely; the coarsely crushed maca is smashed in an ultrasonic mist spray smashing method and made into ultrafine powder with the particle size being 200-300 meshes so that extraction efficiency can be improved; kaoliang spirit at 45% alcohol by volume is made by adding purified water to kaoliang spirit at 60% alcohol by volume in a blending mode, and placed for about one month, so that alcohol molecules and water molecule are fused completely; the maca kaoliang spirit is made of the kaoliang spirit and the maca powder between which the weight ratio is 35:1 in an extracted mode, and the maca kaoliang spirit is 42% alcohol by volume; rough filtration is conducted, and then refined filtration is conducted; the finished wine is sterilized in a bacterium plate filtration sterilization method; the finished wine is packaged.