利索-全球专利检索

  1. 登录
  2. 注册
发明公开
CN103484460A 一种寡核苷酸及其衍生物以及它们的应用 无效 - 撤回

一种寡核苷酸及其衍生物以及它们的应用
摘要：
本发明提供了一种能够下调PML/RARα融合蛋白相关组织因子（TF）高表达的寡核苷酸（5’-cagctccgcgctcggtgg-3’）及其衍生物，以及该寡核苷酸（5’-cagctccgcgctcggtgg-3’）及其衍生物在预防和/或治疗急性白血病及其并发症和/或其它与PML/RARα相关组织因子异常高表达或其受体活性异常改变相关的疾病方面的应用，和/或改善与TF高表达有关的病理现象如凝血障碍等的应用。
摘要（英）：

The invention provides an oligonucleotide (5'-cagctccgcgctcggtgg-3') capable of reducing the high expression of a PML/RARalpha fusion protein related tissue factor (TF), and its derivatives, and applications of the oligonucleotide (5'-cagctccgcgctcggtgg-3') and its derivatives in the prevention and/or treatment of acute leukemia and its complications and/or other PML/RARalpha related tissue factor abnormal-high-expression or its acceptor activity abnormal-change related diseases, and/or the improvement of TF high-expression related pathology phenomena, such as coagulopathy.

0/0