The invention discloses a grouper large scale total-artificial breeding method. The method comprises the steps of parent cultivation, artificial reproduction, offspring seed production, leaving pond of offspring seeds, and temporary rearing in a net cage. The grouper large scale total-artificial breeding method is suitable for seedling cultivation of orange-spotted groupers, or saddletail groupers, or giant groupers, or Hong Kong grouper, or East Star Groupers. The grouper large scale total-artificial breeding method solves the problem that the death rate of groupers in a current seedling cultivation technology is high, and broad prospect of scale development of grouper cultivation is achieved.