The invention discloses an energy-saving waste-utilizing self-insulation concrete which is prepared from the following raw materials in parts by weight: 10000 parts of cement, 6500-7600 parts of 2300-2700 parts of sand, 490-1130 parts of rock wool, 1800-2900 parts of expanded perlite, 110-200 parts of waterproofing agent, 25-57 parts of penetrant and 6000-8000 parts of water. The invention also discloses a preparation method of the energy-saving waste-utilizing self-insulation concrete. The energy-saving waste-utilizing self-insulation concrete can satisfy the requirements of the nation for the energy-saving environment-friendly building material, and can promote the development of the concrete brick masonry material; the self-insulation concrete has the advantages of low heat conductivity coefficient, favorable insulation property and simple preparation technique; and all the materials are inorganic substances, and thus, the self-insulation concrete has stable physicochemical properties.