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发明公开
CN103505445A 二甲双胍的新用途 失效 - 权利终止

二甲双胍的新用途
摘要：
本发明公开了一种二甲双胍的新用途。本发明提供了二甲双胍在制备预防和/或治疗肿瘤产品中的应用。所述肿瘤为子宫内膜癌。所述子宫内膜癌的癌细胞为Ishikawa细胞或HEC-1B细胞。所述产品为药物。本发明的实验证明，本发明发现了二甲双胍抑制子宫内膜癌细胞的增殖，且其的作用半数致死量（IC50值）接近于人体二甲双胍血药浓度，为子宫内膜癌的药物制备奠定了基础，可以用于预防和治疗子宫内膜癌。
摘要（英）：

The invention discloses new application of dimethyldiguanide. The invention provides application of dimethyldiguanide to preparation of products for preventing and/or treating tumor. The tumor is endometrial cancer. The cancer cells of the endometrial cancer are Ishikawa cells or HEC-1B cells. The products are medicines. The experiment of the invention proves that dimethyldiguanide can inhibit proliferation of the endometrial cancer cells and the half lethal dose (IC50 value) of dimethyldiguanide is close to the dimethyldiguanide blood concentration of a human body, so basis is laid for preparation of medicines for the endometrial cancer, and dimethyldiguanide can be used for preventing and treating the endometrial cancer.

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