The invention provides a preparation method of organic/inorganic composite globules. The preparation method comprises the following steps: dissolving polystyrene into polymerization monomer styrene, uniformly dispersing hydrophobic nanometer inorganic particles into the solution, and meanwhile, adding an initiator and a crosslinking agent, uniformly dissolving the components and uniformly dispersing the components in the aqueous solution, heating up to polymerize the monomers, performing suction filtering on the obtained solid phase, and drying to obtain the organic/inorganic composite globules. The temperature resistance of the composite globules prepared by the method is higher than that of pure plastic globules, the particle diameters are uniform, the surfaces are smooth, and the composite globules can be used as solid lubricants for drilling fluids.