The invention discloses health-care wine and a preparation method, belonging to the technical field of brewing. The technical scheme is that the health-care wine is characterized by comprising male silkworm moth extract and mixed extract of velvet, sheep testicle, eucommia bark, astragalus, medlar, epimedium, dodder, tuber onion seed, prepared rhizome of rehmannia, ginseng and salvia miltrorrhiza. Compared with the prior art, the health-care wine and the preparation method have the advantages that the wine keeps the original taste of the spirit and the active ingredients of traditional Chinese medicines are also replenished to prepare the new health-care wine with functions of delaying aging, enhancing the sexual function, improving the immunity, resisting fatigue and strengthening the body; the wine has the prominent substantive characteristic and obvious progress of prominent health-care effect and simple production method.