The invention belongs to the field of pump units, and particularly relates to a centrifugal pump with a self-lubricating bearing and a self-centering function. The centrifugal pump comprises a pump case, a pump impeller, a pump shaft and a driving source, wherein the pump impeller is used for driving a medium in the pump case to flow in a set direction, the pump shaft is used for driving the pump impeller to rotate, and the driving source is at least located at one end of the pump shaft and used for driving the pump shaft to rotate. A pump cavity is formed in the pump case and used for circulation of the medium, the pump shaft penetrates through a pump case body, and the pump impeller on the pump shaft is arranged to be contained in the pump cavity. The centrifugal pump further comprises a bearing assembly used for supporting the pump shaft, and a channel is formed between the position to be lubricated on the bearing assembly and the pump cavity and used for connecting the position to be lubricated and the pump cavity and for circulation of the medium. Liquid state fluidity of the medium self is used for achieving the self-lubricating effect of the bearing assembly, processing technologies of the centrifugal pump are reduced to the great degree, so that the effect of simplifying assembly structures of the centrifugal pump is achieved, and the centrifugal pump is simple in structure, good in stability and high in working reliability.