The invention provides a location fingerprint positioning method and a device thereof, relating to the technical field of wireless positioning. The method comprises a step of carrying out reference point calibration and collecting the signal strength sample value of a calibrated reference point in an area to be positioned, a step of detecting and dividing the area to be positioned into a plurality of sub areas according to the MAC address list of a wireless access point and the largest diameter of a wireless access point coverage area and detecting the MAC address lists of all wireless access points in each of the sub areas, and a step of matching the MAC address lists of wireless access points of target point actual measurement with the MAC address lists of the wireless access points in each of the sub areas and determining the final position of the target point according to a matching result. According to the method and the device, through carrying out reference point calibration in the area to be positioned, high positioning accuracy is obtained, the area to be positioned is divided into a plurality of sub areas, and the computational complexity of high positioning is reduced. In addition, through the reduction of the computational complexity, the real-time positioning of the target point can be realized.