The invention discloses application of ganoderma lucidum extract in preparation of health-care foods or cosmetics with anti-radiation and anti-aging effects. The ganoderma lucidum extract has the effect of anti-UVA (ultraviolet A) radiation, can remarkably reduce cell injury caused by UV (ultraviolet) radiation, has a remarkable inhibition effect on macrophage inflammatory factor expression, can play anti-inflammation and anti-aging effects. The invention also explains the anti-UV radiation and anti-aging effects of ganoderma lucidum extract on the aspects of cell and molecular level. Furthermore, the invention also discloses an optional method for preparing the ganoderma lucidum extract with anti-radiation and anti-aging effects.