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发明公开
CN103575777A N-甲基甘氨酸及其盐类的快速滴定分析方法 无效 - 撤回

N-甲基甘氨酸及其盐类的快速滴定分析方法
摘要：
本发明公开了一种N-甲基甘氨酸及其盐类的快速定量分析方法，涉及一种水溶液中游离酸、羧基酸和氨基酸的快速滴定分析方法，属于定量分析领域。本方法通过将滴定曲线的一阶导数峰值对应的体积为滴定终点。滴定时用强酸将溶液调节至pH值2以下,然后用碱标准溶液滴定，滴定至pH6-7时产生的第一个峰值表示游离强酸被滴定,滴定至pH10.5～11.5时产生第二个峰值表示羧基酸被滴定，接着加入二硫化碳使种N-甲基甘氨酸中的仲胺基发生二硫代甲酰化(DTF)反应，随后继续用碱标准溶液滴定至pH9.5-10.5产生第三个峰值，即可分别计算出溶液中的游离酸、羧基酸和氨基酸的含量。本方法操作简便、快捷、结果可靠、分析成本低。
摘要（英）：

The invention discloses a rapid titration analysis method for N-methylglycine and salts thereof, relates to a rapid titration analysis method for free acids, carboxylic acids and amino acids in an aqueous solution, and belongs to the field of quantitative analysis. Volumes corresponding to first-order derivative peak values of a titration curve are determined as titration end points. The method comprises the following steps of adjusting a pH value of a solution to be less than 2 by using strong acids during titration, performing titration by using a standard alkali solution, generating a first peak value indicating that free strong acids are titrated when the pH value is 6 to 7, generating a second peak value indicating that the carboxylic acids are titrated when the pH value is 10.5 to 11.5, adding carbon disulfide to realize the DTF (dithio-formylation) reaction of a secondary amine group in the N-methylglycine, continuing performing titration by using the standard alkali solution to generate a third peak value until the pH value is 9.5 to 10.5, and calculating the free acid content, carboxylic acid content and amino acid content of the solution respectively. The method can be conveniently and quickly operated, and is low in analysis cost, and a reliable result can be obtained.

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