The invention discloses an intelligent transformer substation process layer communication designing and debugging method. The method comprises the following steps of (1) providing a virtual terminator table of devices to a designing institute according to a uniform standardized design code by a device supplier, and standardizing signal definition and signal sequence inside a virtual terminator; (2) determining a communication relation between devices according to an electrical main connection mode and device configuration of a transformer substation at the design stage by the electric power designing institute; (3) allocating communication parameters including device identification and communication addresses according to the communication relation between the devices provided by the electric power designing institute by an integrator; (4) setting the communication parameters between the devices according to the information provided by the integrator when the intelligent transformer substation is debugged, and automatically matching the communication of virtual terminators between the devices according to the standardized definition and sequence of the virtual terminators. By adopting the method, only the connection between control blocks of the devices needs to be reflected, and the correlation workload among a great number of virtual terminator signals can be alleviated.