The invention belongs to the technology of nuclear power design, and particularly relates to design of an advanced fusion-fission subcritical energy reactor core tritium-production blanket. The advanced fusion-fission subcritical energy reactor core tritium-production blanket structurally comprises multiple layers of tritium-production materials, moderator water is arranged between every two adjacent layers of tritium-production materials, zirconium partition boards are arranged between the tritium-production materials and the moderator water, and a zirconium casing is arranged outside the tritium-production blanket. According to the advanced fusion-fission subcritical energy reactor core tritium-production blanket, the tritium-production materials and the moderator water are arranged at intervals and are separated through zirconium layers with certain thicknesses; interval arrangement is optimized so that the tritium breeding ratio can be as large as possible, and the tritium-production blanket can meet the design requirement for the tritium breeding ratio of a subcritical energy reactor core.