The invention discloses a power amplification device and wireless equipment. The power amplification device comprises a power divider, a carrier frequency amplifier, a peak amplifier and a microstrip line; the input ends of the carrier frequency amplifier and the peak amplifier are respectively connected to the output end of the power divider; both the output end of the carrier frequency amplifier and the output end of the peak amplifier are connected to the input end of the microstrip line; the output end of the peak amplifier is connected with the input end of the microstrip line by adopting an air microstrip line. The power amplification device disclosed by the invention adopts the air microstrip line, so that the layout of a PCB (printed circuit board) and the combination of the carrier frequency amplifier and the peak amplifier in a Doherty power amplifier can be facilitated; moreover, differential loss is low, so that high efficiency and high linearity of the power amplifier are easier to realize.