The invention discloses a wild rhinogobio ventralis continental rise pond net cage domestication method. The method includes four key technical links of the link 1, domestication pond water quality cultivation and regulation and control, specifically, applying liquid state organic fertilizer, composite probiotics and bottom material improvers at regular intervals to carry out water quality cultivation and the regulation and control, the link 2, net case establishment, and specifically a net case is mainly composed of knotless netting and a stainless steel framework and meanwhile is provided with an aeration flow generating device, the link 3, polyculture of wild rhinogobio ventralis and megalobrama pellegrini, specifically, adopting the method that artificial culture breeds are cultured in a matched mode outside the net cage to carry out domestication of wild fishes, and the link 4, ingestion domestication, specifically, adopting the method of food calling first and domestication feeding second, namely, feeding biological baits first then gradually feeding artificial mixed feed. According to the method, domestication of the wild fishes is carried out in a manner that the flow generating type net case is erected in a continental rise pond, meanwhile, the technologies of the water quality regulation and control, polyculture and live bait food calling are utilized comprehensively, and therefore the adaptability of the wild fishes to the culture environment can be promoted, the survival rate of domestication can be improved, and the method has wide application prospect.