The invention relates to a regeneration technology for the molecular distillation treatment of spent lubrication oil. The regeneration technology is characterized in that the regeneration technology comprises the following steps: preprocessing: after the spent lubrication oil is placed in a sedimentation tank for sedimentation, an upper oily mixture is obtained and placed in a plate and frame filter for filtering, so as to obtain a treatment fluid; flocculation: the treatment fluid is heated up to 120-170 DEG C, and during the heating, one fifth of an organic flocculant is added for every temperature rise of 20 DEG C until the organic flocculant is used up; rectification: the flocculated treatment fluid sequentially goes through degasification and drying, and is then transferred into a rectifying tower for rectification; molecular distillation: the rectified lubrication oil further goes through multistage molecular distillation; membrane filtration: the lubrication oil after the molecular distillation goes through membrane filtration to obtain base oil. The invention has the advantages of small investment scale, low operation costs, high quality of regenerated base oil products, high yield, energy conservation, environmental friendliness, high regeneration efficiency and safety, and prevents 'secondary pollution'.