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发明公开
CN103599122A 知母中知母皂苷AⅢ在制备抗肿瘤药物的应用 无效 - 驳回

知母中知母皂苷AⅢ在制备抗肿瘤药物的应用
摘要：
本发明属于药物学领域，公开了在制备抗肿瘤药物中的应用。药理实验证明知母皂苷AⅢ具有广谱且较强的抗肿瘤活性，尤其对T475-S2细胞具有强且稳定的细胞毒性，且比5-Fu和紫杉醇杀伤T475-S2细胞能力更强，24h的IC50为6.97±0.72µM，24h，AⅢ用药浓度为6µM，能够诱导T475-S2细胞的凋亡与自噬，凋亡作用一直处于主导位置，从而使知母皂苷AⅢ可用于制备预防和治疗肿瘤的药物。
摘要（英）：

The invention discloses application of timosaponin AIII in anemarrhena to preparation of antitumor drugs, which belongs to the field of pharmacology. Pharmacological experiments prove that timosaponin AIII has broad-spectrum strong antineoplastic activity, especially strong and stable cytotoxicity on T475-S2 cells; timosaponin AIII has stronger capacity in killing T475-S2 cells compared with 5-Fu and paclitaxel; the IC50 value of timosaponin AIII is 6.97 +- 0.72 mu M after 24 h, the concentration of used timosaponin AIII is 6 mu M, timosaponin AIII can induce apoptosis and autophagy of T475-S2 cells, the effect of apoptosis is dominating, so timosaponin AIII can be used for preparing drugs for preventing and treating tumors.

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