The invention discloses the technical field of synthesis of isotope labeled compounds and particularly relates to a synthesis method of C13-labelled DDT (Dichlorodiphenyl Trichloroethane), DDD (Dichlorodiphenyl Dichloroethane) and DDE (Dichlorodiphenyl Dichloroethene). The synthesis method comprises the following steps: with 13C6-benzene as a raw material, carrying out oxychlorination to obtain 12C6-chlorobenzene, carrying out acid catalytic condensation on the 12C6-chlorobenzene with a trichloracetic aldehyde hydrate and a dichloroacetaldehyde hydrate respectively to obtain 13C12-DDT and 13C12-DDD, and preparing 13C12-DDE by carrying out catalytic dehydrochlorination on 13C12-DDT by means of a phase transfer catalyst. A series of representations prove that the products are 13C12-DDT, 13C12-DDD and 13C12-DDE, and the chemical purity of the products reaches above 90 percent, and the stable isotope abundance is above 90 percent.