The invention relates to a novel self-luminous building brick comprising a base material layer, a self-luminous layer and a self-cleaning layer. The surface of the base material layer is provided with the self-luminous layer, the surface of the self-luminous layer is provide with the self-cleaning layer, the self-luminous layer comprises luminescent powder, an accelerant, a hardener, fluoropolymer and transparent resin, and the self-cleaning layer comprises nano aluminium oxide, nano silicon oxide, nano titanium oxide, a defoamer and a dispersant. The self-luminous layer can absorb light rays of different wavebands and has the advantages of energy storage and high luminous intensity, and lighting time is prolonged; the self-cleaning layer has high antifouling and self-cleaning performances, fouling such as dust and oil fouling falling on the surface of the novel self-luminous building brick can be cleaned by only depending on washing of rainwater without being cleaned by labor, good using effect during using can be guaranteed, and use and maintenance cost during use is lowered greatly.