The invention discloses a method of arsenic removal in a direct reduction process. The method comprises the following steps: grinding a material containing arsenic; adding a reducing agent and a binder into the material; evenly mixing and pelletizing; drying the prepared pellets and placing in a reduction furnace; and performing a direct reduction reaction by controlling a reaction temperature and a furnace inside atmosphere, thereby removing the arsenic and performing direct reduction on valuable metals at the same time. According to the method, the arsenic removal and the reduction treatment of the valuable metals are realized at the same time.