The invention provides a transmission power line spacer replacement tool. The transmission power line spacer replacement tool includes a screw rod and an operating handle; an end portion of the screw rod is provided with a working head; the operating handle drives the working head to rotate through the screw rod; a looseness-to-tightness conversion device is arranged between the operating handle and the screw rod; the looseness-to-tightness conversion device comprises a transmission clutch assembly and a driving piece; the transmission clutch assembly has a separation state and an engaged state; the operating handle drives the screw rod to rotate under the engaged state of the transmission clutch assembly; and the driving piece drives the transmission clutch assembly to be switched between the separation state and the engaged state. According to the transmission power line spacer replacement tool of the invention, a sleeve is mounted on the screw rod provided with a clamping pin, and therefore, an operator does not need a special sleeve tool when requiring a sleeve, and the operator only needs to change the direction of the replacement tool so as to use the sleeve; and at the same time, after the looseness-to-tightness conversion device is mounted, the angle of the operating handle can be adjusted whenever only with switching the looseness-to-tightness conversion device required, and therefore, the operator is not limited spatially, and thus, maintenance and repair operation of the operator can be facilitated.