The invention discloses a 2-Acryloylamino-2-methyl-1-propanesulfonic acid (AMPS)-methyl methacrylate (MMA)-halloysite copolymerized denture base material and preparation method thereof. According to the invention, the charge environment of the polymer substrate of the first monomer MMA is regulated and controlled through the second monomer AMPS, the two monomers are copolymerized through the suspension polymerization method, HNTs is added and compounded with the copolymerization product, and after the copolymerization product is mixed with thermosetting type dental base acrylic resin liquid, the mixture is heated and cured. According to the invention, the MMA is used as a base material, and the in situ suspension polymerization method is adopted to prepare a nanocomposite to regulate and control the charge environment of the substrate, and the halloysite filler is added for polymerization, so that relatively pure PMMA resin is obtained, the bending strength and tensile strength are improved to a great extent, the dispersity of halloysite in the substrate is successfully improved, and the problem about the mechanical strength, particularly the bending strength of the PMMA denture base material, is solved.