The invention provides fruit-grain nutritious bread and a making method thereof. The fruit-grain nutritious bread comprises, by weight, 30-45 parts of flour, 10-25 parts of whole wheat flour, 10-25 pats of wheat fiber flour, 10-15 parts of sorghum flour, 2-5 parts of mandarin orange, 2-5 parts of orange, 3-6 parts of apple, 4-8 parts of honey, 1-3 parts of malt syrup, 1-3 parts of stevioside, 8-12 parts of milk, 5-8 parts of egg, 2-4 parts of yeast, and 5-10 parts of purified water. The making method includes: peeling and chopping mandarin oranges, oranges and apples, juicing, using other ingredients to form a dough for fermentation, mixing the juice with the fermented dough, fermenting, and baking. The fruit-grain nutritious bread is rich in fruit and grain fibers, low in calories, simple in making process, low in cost and suitable for industrial production.