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发明公开
CN103665163A 抗骨桥蛋白抗体及其应用 有权

抗骨桥蛋白抗体及其应用
摘要：
本发明公开了一种抗骨桥蛋白抗体及其应用，所述抗骨桥蛋白抗体包括重链可变区和轻链可变区，所述重链可变区的三个高变区CDRH1、CDRH2、CDRH3的氨基酸序列分别为：GFSLSTSGE、YWDDD、RGFDGSGYYSYFEH，所述轻链可变区的三个高变区CDRL1、CDRL2、CDRL3的氨基酸序列分别为：TRSSGSIASNYVQ、EDNQRPS、HSYDSSFHWV。本发明还公开了所述抗骨桥蛋白抗体在制备检测卵巢癌细胞和肺癌细胞的试剂中的应用。本发明抗骨桥蛋白抗体特异性高，制备过程相对简单，成本低廉。
摘要（英）：

The invention discloses an anti-osteopontin antibody and application of the anti-osteopontin antibody. The anti-osteopontin antibody comprises a heavy chain variable region and a light chain variable region, wherein the amino acid sequences of three hypervariable regions (CDRH1, CDRH2 and CDRH3) in the heavy chain variable region are as follows respectively: GFSLSTSGE, YWDDD and RGFDGSGYYSYFEH; and the amino acid sequences of three hypervariable regions (CDRL1, CDRL2 and CDRL3) in the light chain variable region are as follows respectively: TRSSGSIASNYVQ, EDNQRPS and HSYDSSFHWV. The invention also discloses application of the anti-osteopontin antibody for preparing reagents for detecting ovarian carcinoma cells and lung carcinoma cells. The anti-osteopontin antibody has high specificity, the preparation process is simple and the cost is low.

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