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发明公开
CN103667285A 可防治流感的siRNA及其药物组合物、医药用途 失效 - 权利终止

可防治流感的siRNA及其药物组合物、医药用途
摘要：
本发明公开了一种可防治流感的靶向ST6GAL1和ST3GAL4基因的siRNA，所述siRNA为以下至少一种：siST6GAL1_001，siST6GAL1_002，siST3GAL4_001，siST3GAL4_002。本发明还提供活性成份为所述siRNA的药物组合物；本发明还提供了所述siRNA在制备可防治流感病毒的药物组合物、药物以及预防制剂中的应用。采用本发明，可以抑制人呼吸道上皮细胞表面的人源甲型流感病毒唾液酸受体以及禽源甲型流感病毒唾液酸受体的表达，从而可以有效地减少人源及禽源甲型流感病毒的吸附与感染。且在呼吸道上皮细胞系，所述siRNA有效率达80%以上。
摘要（英）：

The invention discloses a siRNA (small interfering Ribose Nucleic Acid) of targeting genes ST6GAL1 and ST3GAL4 capable of preventing and controlling influenza. The siRNA comprises at least one of siST6GAL1_001, siST6GAL1_002, siST3GAL4_001, and siST3GAL4_002. The invention also provides a pharmaceutical composition of which the siRNA serves as an effective ingredient. The invention also provides an application of the siRNA in preparation of the pharmaceutical composition, a medicine and a prevention preparation for preventing and controlling influenza virus. By adopting the pharmaceutical composition, medicine and prevention preparation, the expression of a human influenza A virus sialic acid receptor and an avian influenza A virus sialic acid receptor on the surface of epithelial cell of human respiratory tract can be inhibited, thus the adsorption and infection of human and avian influenza A virus can be reduced effectively; in addition, the effective rate of the siRNA reaches more than 80% in the respiratory tract epithelial cell line.

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